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Article

Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands.

Nucleic acids research - 1 Jun 2014

Talhaoui Ibtissam, Couve Sophie, Gros Laurent, Ishchenko Alexander A, Matkarimov Bakhyt, Saparbaev Murat K

Abstract excerpt

The human thymine-DNA glycosylase (TDG) initiates the base excision repair (BER) pathway to remove spontaneous and induced DNA base damage. It was first biochemically characterized for its ability to remove T mispaired with G in CpG context. TDG is involved in the epigenetic regulation of gene expressions by protecting CpG-rich promoters from de novo DNA methylation. Here we demonstrate that TDG initiates...

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PMID: 24692658
DOI: 10.1093/nar/gku246
PMCID: PMC4041421

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TDG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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