Article
Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands.
Nucleic acids research - 1 Jun 2014
Talhaoui Ibtissam, Couve Sophie, Gros Laurent, Ishchenko Alexander A, Matkarimov Bakhyt, Saparbaev Murat K
Abstract excerpt
The human thymine-DNA glycosylase (TDG) initiates the base excision repair (BER) pathway to remove spontaneous and induced DNA base damage. It was first biochemically characterized for its ability to remove T mispaired with G in CpG context. TDG is involved in the epigenetic regulation of gene expressions by protecting CpG-rich promoters from de novo DNA methylation. Here we demonstrate that TDG initiates...
Topics
- Adenine
- Animals
- Base Pair Mismatch
- Cells, Cultured
- CpG Islands
- DNA
- DNA Damage
- DNA Repair
- Humans
- Mice
- Mutation
- Oligonucleotides
- Polymorphism, Single Nucleotide
- Thymine
- Thymine DNA Glycosylase