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Article

MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles.

Mutation research - 1 Jan 2000

Sjolund Ashley B, Senejani Alireza G, Sweasy Joann B

Abstract excerpt

The base excision repair system is vital to the repair of endogenous and exogenous DNA damage. This pathway is initiated by one of several DNA glycosylases that recognizes and excises specific DNA lesions in a coordinated fashion. Methyl-CpG Domain Protein 4 (MBD4) and Thymine DNA Glycosylase (TDG) are the two major G:T glycosylases that remove thymine generated by the deamination of 5-methylcytosine. Both of...

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Source

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Identifiers

PMID: 23195996
DOI: 10.1016/j.mrfmmm.2012.11.001
PMCID: PMC3661743

Genes

MBD4
TDG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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