Article
Preferential CEBP binding to T:G mismatches and increased C-to-T human somatic mutations.
Nucleic acids research - 21 May 2021
Yang Jie, Horton John R, Akdemir Kadir C, Li Jia, Huang Yun, Kumar Janani, Blumenthal Robert M, Zhang Xing, Cheng Xiaodong
Abstract excerpt
DNA cytosine methylation in mammals modulates gene expression and chromatin accessibility. It also impacts mutation rates, via spontaneous oxidative deamination of 5-methylcytosine (5mC) to thymine. In most cases the resulting T:G mismatches are repaired, following T excision by one of the thymine DNA glycosylases, TDG or MBD4. We found that C-to-T mutations are enriched in the binding sites of CCAAT/enhancer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.