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Article

Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis.

Acta biochimica et biophysica Sinica - 1 Jan 2016

Xu Xuehe, Watt David S, Liu Chunming

Abstract excerpt

Thymine DNA glycosylase (TDG) is a multifunctional protein that plays important roles in DNA repair, DNA demethylation, and transcriptional regulation. These diverse functions make TDG a unique enzyme in embryonic development and carcinogenesis. This review discusses the molecular function of TDG in human cancers and the previously unrecognized value of TDG as a potential target for drug therapy.

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Topics

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Share to Carcinogenesis
Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Gene Expression Regulation, Neoplastic

Share to Neoplasms

Share to Protein Processing, Post-Translational

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Source

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Identifiers

PMID: 26370152
DOI: 10.1093/abbs/gmv083
PMCID: PMC4689155

Genes

TDG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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