Article

Alignment free identification of clones in B cell receptor repertoires

2020-03-31

Abstract excerpt

Following pathogenic challenge, activated B cells rapidly expand and undergo somatic hypermutation, yielding groups of clonally related B-cells with diversified immunoglobulin receptors. Inference of clonal relationships based on the receptor sequence is an essential step in many adaptive immune receptor repertoire sequencing studies. These relationships are typically identified by a multi-step process that involv...

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Literature Corpus work: dcc7cbc7-a517-5cb5-a41a-61c87a0cb9be
DOI: 10.1101/2020.03.30.017384

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