Article

Immunoglobulin heavy chains are sufficient to determine most B cell clonal relationships <sup>1</sup>

2019-06-10

Abstract excerpt

B cell clonal expansion is vital for adaptive immunity. High-throughput B cell receptor (BCR) sequencing enables investigating this process, but requires computational inference to identify clonal relationships. This inference usually relies on only the BCR heavy chain, as most current protocols do not preserve heavy:light chain pairing. The extent to which paired light chains aids inference is unknown. Using huma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1d2d9aa-aaf8-55d3-b8b5-73b5df8629d5
DOI: 10.1101/665760

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunoglobulin heavy chains are sufficient to determine most B cell clonal relationships <sup>1</sup>DOI 10.1101/665760Read

Cutting Edge: Ig H Chains Are Sufficient to Determine Most B Cell Clonal RelationshipsSemantic proximity Read

Hierarchical Clustering Can Identify B Cell Clones with High Confidence in Ig Repertoire Sequencing DataSemantic proximity Read

Systematic evaluation of B-cell clonal family inference approaches.Semantic proximity Read

Inferring B cell phylogenies from paired heavy and light chain BCR sequences with DowserSemantic proximity Read

Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing dataSemantic proximity Read

A Public Database of Memory and Naive B-Cell Receptor SequencesSemantic proximity Read

Combining mutation and recombination statistics to infer clonal families in antibody repertoires.Semantic proximity Read

Computational Evaluation of B-Cell Clone Sizes in Bulk PopulationsSemantic proximity Read

EuroClonality-NGS Recommendations for Evaluation of B-Cell Clonality Analysis by Next-Generation SequencingSemantic proximity Read

Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing data.Semantic proximity Read

Reading the B-cell receptor immunome in chronic lymphocytic leukemia: revelations and applications.Semantic proximity Read

Combining mutation and recombination statistics to infer clonal families in antibody repertoiresSemantic proximity Read