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Article

A spectral clustering-based method for identifying clones from high-throughput B cell repertoire sequencing data

13 Apr 2018

Abstract excerpt

Motivation: B cells derive their antigen-specificity through the expression of Immunoglobulin (Ig) receptors on their surface. These receptors are initially generated stochastically by somatic re-arrangement of the DNA and further diversified following antigen-activation by a process of somatic hypermutation, which introduces mainly point substitutions into the receptor DNA at a high rate. Recent advances in...

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PMID: 29949968
DOI: 10.1093/bioinformatics/bty235

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