Article

Focused CRISPR-Cas9 screens investigating the DNA damage response

2020-01-01

Abstract excerpt

The DNA damage response (DDR) consists of a complex network of interconnected pathways which detect and repair damaged DNA, maintaining genome integrity. Somatic mutations in DDR genes are associated with tumour development, while germline mutations cause a spectrum of disorders ranging from inherited cancer predisposition syndromes to developmental disorders. Genetic screens can be used to gain insights into the...

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Literature Corpus work: dcb3dc8a-a12e-57e5-a637-22439fc8255a
DOI: 10.17863/cam.68473

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