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Article

The central role of macrophages in skeletal muscle regeneration: Phenotypic Polarization, metabolic reprogramming, and therapeutic prospects.

Biochemical pharmacology - 1 Aug 2026

Liu Ruiqi, Shen Yuntian, Wei Yutong, Zhu Chuli, Yao Xinlei, Gu Xiaosong, Qi Lei, Sun Hualin

Abstract excerpt

Macrophages are central regulators of skeletal muscle regeneration, dynamically transitioning from pro-inflammatory (M1-like) to reparative (M2-like) phenotypes to coordinate debris clearance, inflammation modulation, satellite cell activation, and tissue remodeling. This review details the underlying molecular mechanisms, focusing on metabolic reprogramming, such as the shift to oxidative phosphorylation and key...

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Identifiers

PMID: 42069229
DOI: 10.1016/j.bcp.2026.118025

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CCR2
CCR5
DMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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