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Article

Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support.

Nature cardiovascular research - 1 Jun 2024

Amoedo-Leite Catarina, Parv Kristel, Testini Chiara, Herrera-Hidalgo Carmen, Xu Feifei, Giraud Antoine, Malaquias Marta, Fasterius Erik, Holl Daniel, Seignez Cedric, Göritz Christian, Christoffersson Gustaf, Phillipson Mia

Abstract excerpt

Sterile inflammation after injury is important for tissue restoration. In injured human and mouse tissues, macrophages were recently found to accumulate perivascularly. This study investigates if macrophages adopt a mural cell phenotype important for restoration after ischemic injury. Single-cell RNA sequencing of fate-mapped macrophages from ischemic mouse muscles demonstrates a macrophage-toward-mural cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39196227
DOI: 10.1038/s44161-024-00478-0
PMCID: PMC11358018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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