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Article

ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2023

Babu Mohan, Devi Durga, Mäkinen Petri, Örd Tiit, Aavik Einari, Kaikkonen Minna, Ylä-Herttuala Seppo

Abstract excerpt

BACKGROUND: Diabetes is a major risk factor for peripheral arterial disease. Clinical and preclinical studies suggest an impaired collateral remodeling and angiogenesis in response to atherosclerotic arterial occlusion in diabetic conditions, although the underlying mechanisms are poorly understood. OBJECTIVE: To clarify the cellular and molecular mechanisms underlying impaired postischemic adaptive vascular...

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Identifiers

PMID: 36384268
DOI: 10.1161/ATVBAHA.122.318196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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