Article

Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells

2023-04-03

Abstract excerpt

<h4>ABSTRACT</h4> Chronic limb-threatening ischemia (CLTI), representing the end-stage of peripheral arterial disease (PAD), is associated with a one-year limb amputation rate of ∼15-20% and significant mortality. A key characteristic of CLTI is the failure of the innate regenerative capacity of skeletal muscle, though the underlying mechanisms remain unclear. Here, single-cell transcriptome analysis of ischemic...

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Literature Corpus work: 57aee7c6-030d-5631-a946-4c2d70d6ce64
DOI: 10.1101/2023.04.01.535211

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