Article

GATA3-extension mutants rewire lineage identity in luminal breast cancer

2026-08-24

Abstract excerpt

GATA3, one of the most frequently mutated transcription factors in breast cancers, is a master regulator of luminal epithelial identity. Unlike many truncating and splice-site GATA3 mutations that disrupt one of the two zinc finger DNA-binding domains, C-terminal extension mutations (eGATA3) retain both of them. This raises the question of whether the eGATA3 mutants can alter transcriptional regulation and thereby...

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Literature Corpus work: dcb03e65-74d8-584b-997b-ad61a3f0a15b
DOI: 10.64898/2026.08.22.746471

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