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GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network

7 Mar 2018

Abstract excerpt

GATA3 is frequently mutated in breast cancer; these mutations are widely presumed to be loss-of function despite a dearth of information regarding their effect on disease course or their mechanistic impact on the breast cancer transcriptional network. Here, we address molecular and clinical features associated with GATA3 mutations. A novel classification scheme defines distinct clinical features for patients...

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PMID: 29535312
DOI: 10.1038/s41467-018-03478-4

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