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Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4 <sup>+</sup> cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype

2024-09-24

Abstract excerpt

Despite efforts to understand breast cancer biology, metastatic disease remains a clinical challenge. Identifying suppressors of breast cancer progression and mechanisms of transition to more invasive phenotypes could provide game changing therapeutic opportunities. Transcriptional deregulation is central to all malignancies, highlighted by the extensive reprogramming of regulatory elements that underlie oncogenic...

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Literature Corpus work
622a2c48-6342-53d3-9a61-13ec159e863a
DOI
10.1101/2024.09.21.614267
Open publication

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Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4 <sup>+</sup> cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotypeDOI 10.1101/2024.09.21.614267
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