Article

An interferon-independent innate immune response to double stranded RNA in embryonic stem cells

2026-03-26

Abstract excerpt

In vertebrate early embryos and embryonic stem cells, the interferon (IFN)–centered double-stranded RNA (dsRNA) sensing and signaling pathway is markedly suppressed, implying the existence of an alternative repertoire of dsRNA sensors in these stages. We recently reported that dsRNA treatment triggers translation inhibition using Prkra as a sensor in zebrafish and mouse early embryos. Independently, here we show t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dcacfb73-2616-5cb0-9584-6604ce8dd072
DOI: 10.64898/2026.03.24.713854

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An interferon-independent innate immune response to double stranded RNA in embryonic stem cellsDOI 10.64898/2026.03.24.713854Read

DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε DegradationSemantic proximity Read

The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.Semantic proximity Read

DDX RNA helicases: key players in cellular homeostasis and innate antiviral immunitySemantic proximity Read

An isoform of Dicer protects mammalian stem cells against multiple RNA virusesSemantic proximity Read

DDX50 is a viral restriction factor that enhances TRIF-dependent IRF3 activationSemantic proximity Read

DHX15 Is a Coreceptor for RLR Signaling That Promotes Antiviral Defense Against RNA Virus InfectionSemantic proximity Read

The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2Semantic proximity Read

DDX50 Is a Viral Restriction Factor That Enhances IRF3 ActivationSemantic proximity Read

Chicken DDX1 Acts as an RNA Sensor to Mediate IFN-β Signaling Pathway Activation in Antiviral Innate ImmunitySemantic proximity Read

Host Cellular RNA Helicases Regulate SARS-CoV-2 InfectionSemantic proximity Read

Genome-Wide CRISPR Screening Identifies BRD9 as a Druggable Component of Interferon-Stimulated Gene Expression and Antiviral ActivitySemantic proximity Read

Human DICER helicase domain recruits PKR and modulates its antiviral activitySemantic proximity Read