Article

Human DICER helicase domain recruits PKR and modulates its antiviral activity

2020-05-15

Abstract excerpt

The antiviral innate immune response mainly involves type I interferon (IFN) in mammalian cells. The contribution of the RNA silencing machinery remains to be established, but several recent studies indicate that the ribonuclease DICER can generate viral siRNAs in specific conditions. It has also been proposed that type I IFN and RNA silencing could be mutually exclusive antiviral responses. In order to decipher t...

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Literature Corpus work: 26459f99-a2e6-5c72-a7f2-0a042c29000c
DOI: 10.1101/2020.05.14.095356

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