Article

DDX50 is a viral restriction factor that enhances TRIF-dependent IRF3 activation

2020-08-06

Abstract excerpt

The transcription factors IRF3 and NF-κB are crucial in innate immune signalling in response to many viral and bacterial pathogens. However, mechanisms leading to their activation remain incompletely understood. Canonical RLR signalling and detection of viral RNA is dependent upon the receptors RIG-I, MDA5 and TLR3. Alternatively, the DExD-Box RNA helicases DDX1-DDX21-DHX36 activate IRF3/NF-κB in a TRIF-dependent...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3059e8af-9115-57fa-b980-9e1ce77c357a
DOI: 10.1101/2020.08.06.239376

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DDX50 is a viral restriction factor that enhances TRIF-dependent IRF3 activationDOI 10.1101/2020.08.06.239376Read

DDX50 Is a Viral Restriction Factor That Enhances IRF3 ActivationSemantic proximity Read

DDX RNA helicases: key players in cellular homeostasis and innate antiviral immunitySemantic proximity Read

DHX15 Is a Coreceptor for RLR Signaling That Promotes Antiviral Defense Against RNA Virus InfectionSemantic proximity Read

Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?Semantic proximity Read

DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε DegradationSemantic proximity Read

RNA helicase DDX3: at the crossroad of viral replication and antiviral immunitySemantic proximity Read

The human DEAD-box protein DDX3X regulates host and viral mRNA translation during Sendai Virus infectionSemantic proximity Read

The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.Semantic proximity Read

RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune SignalingSemantic proximity Read

Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptorsSemantic proximity Read

Discrimination of cytosolic self and non-self RNA by RIG-I-like receptorsSemantic proximity Read

Chicken DDX1 Acts as an RNA Sensor to Mediate IFN-β Signaling Pathway Activation in Antiviral Innate ImmunitySemantic proximity Read