Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation

1 Jan 2019

Abstract excerpt

DExD/H-box helicase members are key receptors for recognizing viral nucleic acids, and they regulate retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated type I interferon (IFN) production. Here, we report that the DExD/H-box helicase family member DExD/H-box RNA helicase 19 (DDX19) is a negative regulator of type I IFN production. Ectopic expression of DDX19 suppressed poly(I:C)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to interferon and immune responses
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30699353
DOI: 10.1016/j.celrep.2019.01.029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε DegradationPMID 30699353Read ↗

DDX50 Is a Viral Restriction Factor That Enhances IRF3 ActivationSemantic proximity Read ↗

DDX50 is a viral restriction factor that enhances TRIF-dependent IRF3 activationSemantic proximity Read ↗

DHX15 Is a Coreceptor for RLR Signaling That Promotes Antiviral Defense Against RNA Virus InfectionSemantic proximity Read ↗

DDX RNA helicases: key players in cellular homeostasis and innate antiviral immunitySemantic proximity Read ↗

The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.Semantic proximity Read ↗

RNA helicase DDX3: at the crossroad of viral replication and antiviral immunitySemantic proximity Read ↗

An interferon-independent innate immune response to double stranded RNA in embryonic stem cellsSemantic proximity Read ↗

DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.Semantic proximity Read ↗

The DEAD‐box helicase DDX3X is a critical component of the TANK‐binding kinase 1‐dependent innate immune responseSemantic proximity Read ↗

Host Cellular RNA Helicases Regulate SARS-CoV-2 InfectionSemantic proximity Read ↗

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.Semantic proximity Read ↗

Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.