Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chicken DDX1 Acts as an RNA Sensor to Mediate IFN-β Signaling Pathway Activation in Antiviral Innate Immunity

23 Sept 2021

Abstract excerpt

Chickens are the natural host of Newcastle disease virus (NDV) and avian influenza virus (AIV). The discovery that the RIG-I gene, the primary RNA virus pattern recognition receptor (PRR) in mammals, is naturally absent in chickens has directed attention to studies of chicken RNA PRRs and their functions in antiviral immune responses. Here, we identified Asp-Glu-Ala-Asp (DEAD)-box helicase 1 (DDX1) as an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immune Response and Inflammation
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34630423
DOI: 10.3389/fimmu.2021.742074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chicken DDX1 Acts as an RNA Sensor to Mediate IFN-β Signaling Pathway Activation in Antiviral Innate ImmunityPMID 34630423Read ↗

The long non-coding RNA lncRNA-DRNR targets the JMJD6 to enhance replication of infectious bronchitis virus（IBV） by influencing the ISG expression pathway through the JAK-STAT signaling pathwaySemantic proximity Read ↗

DDX50 is a viral restriction factor that enhances TRIF-dependent IRF3 activationSemantic proximity Read ↗

A novel short transcript isoform of chicken IRF7 negatively regulates interferon-β productionSemantic proximity Read ↗

Duck MDA5 functions in innate immunity against H5N1 highly pathogenic avian influenza virus infectionsSemantic proximity Read ↗

DDX50 Is a Viral Restriction Factor That Enhances IRF3 ActivationSemantic proximity Read ↗

Targeted knockout of Mx in the DF-1 chicken fibroblast cell line impairs immune response against Newcastle disease virusSemantic proximity Read ↗

Innate sensing of viruses by pattern recognition receptors in birdsSemantic proximity Read ↗

Characterization of Chicken Mda5 Activity: Regulation of IFN-β in the Absence of RIG-I FunctionalitySemantic proximity Read ↗

Avian IRF1 and IRF7 Play Overlapping and Distinct Roles in Regulating IFN-Dependent and -Independent Antiviral Responses to Duck Tembusu Virus InfectionSemantic proximity Read ↗

Chicken Cells Sense Influenza A Virus Infection through MDA5 and CARDIF Signaling Involving LGP2Semantic proximity Read ↗

DDX RNA helicases: key players in cellular homeostasis and innate antiviral immunitySemantic proximity Read ↗

Untangling the roles of RNA helicases in antiviral innate immunitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.