Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection

Abstract excerpt

SARS-CoV-2 has a large RNA genome, of approximately 30 kb. To regulate and maintain such a large viral RNA genome, host RNA helicases may be involved in SARS-CoV-2 replication. In this study, I have demonstrated that DDX21 and MOV10 RNA helicases limit viral infection and replication. In contrast, DDX1, DDX5, and DDX6 are required for SARS-CoV-2 infection. Interestingly, SARS-CoV-2 infection disrupted P-body...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to RNA regulation and disease
• Share to RNA Research and Splicing
• Share to Viral gastroenteritis research and epidemiology