Genome-Wide CRISPR Screening Identifies BRD9 as a Druggable Component of Interferon-Stimulated Gene Expression and Antiviral Activity

Abstract excerpt

<h4>ABSTRACT</h4> Transient interferon (IFN) induction of IFN-stimulated genes (ISGs) creates a formidable protective antiviral state. However, loss of appropriate control mechanisms can result in constitutive pathogenic ISG upregulation. Here, we used genome-wide loss-of-function screening to establish genes critical for IFN signaling, identifying all expected members of the JAK-STAT pathway and the previously u...

Topics

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• Cytokine Signaling Pathways and Interactions
• interferon and immune responses
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• RNA regulation and disease
• Viral Infections and Immunology Research
• Viral Infections and Vectors

Identifiers and source

Literature Corpus work

397031d7-3ac8-5839-8642-f2366b2f2fed

DOI

10.1101/2021.02.04.429732