Article

Reelin haploinsufficiency affects skilled motor performance associated with suppression of training-induced gene enrichment, synaptic function and activity-dependent cortical plasticity in mice

2020-10-26

Abstract excerpt

RELN (Reelin) is one of the genes implicated in neurodevelopmental psychiatric vulnerability. Patients with neurodevelopmental disorders can experience impairments in fine motor skills. While Reelin modulates synaptic function, whether Reelin haploinsufficiency affects activity-dependent cortical plasticity which supports development of skilled movement is unclear. Here, heterozygous Reeler mutant (HRM) and Dab1...

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Literature Corpus work: dca7c671-54f7-55ed-9112-1d106490f6b0
DOI: 10.1101/2020.10.25.351528

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