Article
Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice.
Neurobiology of learning and memory - 1 May 2006
Qiu Shenfeng, Korwek Kimberly M, Pratt-Davis Adeola R, Peters Melinda, Bergman Mica Yael, Weeber Edwin J
Abstract excerpt
The heterozygote reeler mouse (HRM) shows many neuroanatomical and biochemical features that are also present in some human cognitive disorders, such as schizophrenia. In the present study, hippocampal dependent plasticity and cognitive function of the HRM were characterized in detail in an attempt to reveal phenotypic functional differences that result from Reelin haploinsufficiency. The HRM and wild type mice...
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