Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration.

Cerebral cortex (New York, N.Y. : 1991) - 30 Jul 2020

Kiroski Ivana, Jiang Yulan, Gavrilovici Cezar, Gao Fan, Lee Sukyoung, Scantlebury Morris H, Vandal Milene, Park Sang Ki, Tsai Li-Huei, Teskey G Campbell, Rho Jong M, Nguyen Minh Dang

Abstract excerpt

The glycoprotein Reelin maintains neuronal positioning and regulates neuronal plasticity in the adult brain. Reelin deficiency has been associated with neurological diseases. We recently showed that Reelin is depleted in mice with a targeted disruption of the Ndel1 gene in forebrain postnatal excitatory neurons (Ndel1 conditional knockout (CKO)). Ndel1 CKO mice exhibit fragmented microtubules in CA1 pyramidal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CA1 Region, Hippocampal
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cognition

Share to Longevity

Share to Memory Disorders

Share to Mice, Knockout

Share to Reelin Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 32328622
DOI: 10.1093/cercor/bhaa088
PMCID: PMC7391417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration.PMID 32328622Read ↗

Reelin supplementation recovers synaptic plasticity and cognitive deficits in a mouse model for Angelman syndromeSemantic proximity Read ↗

Novel genetic tools facilitate the study of cortical neuron migration.Semantic proximity Read ↗

Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells.Semantic proximity Read ↗

Reelin: Diverse roles in central nervous system development, health and diseaseSemantic proximity Read ↗

Reelin down-regulation in mice and psychosis endophenotypes.Semantic proximity Read ↗

Transient downregulation of Dab1 protein levels during development leads to behavioral and structural deficits: relevance for psychiatric disorders.Semantic proximity Read ↗

Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability.Semantic proximity Read ↗

A protein related to extracellular matrix proteins deleted in the mouse mutant reeler.Semantic proximity Read ↗

Axonopathy and altered synaptic development in early hippocampal epileptogenesis of Dravet syndromeSemantic proximity Read ↗

Serum response factor regulates hippocampal lamination and dendrite development and is connected with reelin signaling.Semantic proximity Read ↗

Reelin haploinsufficiency affects skilled motor performance associated with suppression of training-induced gene enrichment, synaptic function and activity-dependent cortical plasticity in miceSemantic proximity Read ↗

Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.