Article

Hyperactivation of MEK1 in cortical glutamatergic neurons results in projection axon deficits and aberrant motor learning

2023-11-07

Abstract excerpt

Abnormal Extracellular Regulated Kinase 1/2 (ERK1/2) signaling is linked to multiple neurodevelopmental diseases, especially the RASopathies, which typically exhibit ERK1/2 hyperactivation in neurons and non-neuronal cells. To better understand how excitatory neuron-autonomous ERK1/2 activity regulates the development of the mouse motor cortex, we conditionally expressed a hyperactive MEK1 S217/221E variant using...

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Literature Corpus work: 01c17c1d-d2eb-5cb0-aeaa-87b3b926a525
DOI: 10.1101/2023.11.06.565901

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