Article

The <em>Reeler</em> Mouse: A Translational Model of Human Neurological Conditions or Simply a Good Tool for Better Understanding Neurodevelopment?

2019-10-10

Abstract excerpt

The Reeler mutation was described in mouse more than fifty year ago. Later, its causative gene (reln) was discovered in mouse, and its human orthologue (RELN) was demonstrated to be causative of lissencephaly 2 (LIS2) and about 20% of the cases of autosomal-dominant lateral temporal epilepsy (ADLTE). In both human and mice the gene encodes for a glycoprotein referred to as Reelin (Reln) that plays a primary role i...

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Literature Corpus work: b7480c5d-5d23-58f5-a2f7-132899bf79ff
DOI: 10.20944/preprints201910.0120.v1

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