Reelin down-regulation in mice and psychosis endophenotypes.

doi:10.1016/j.neubiorev.2006.04.001

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Article

Reelin down-regulation in mice and psychosis endophenotypes.

Neuroscience and biobehavioral reviews - 1 Jan 2006

Tueting Patricia, Doueiri Mohemed-Salim, Guidotti Alessandro, Davis John M, Costa Erminio

Abstract excerpt

Reelin, a large glycoprotein secreted by telencephalic GABAergic neurons, plays an important role in neuronal guidance embryonically and in synaptic plasticity postnatally. The reeler heterozygous mouse (+/rl) appears superficially normal but has been of interest as an animal model for psychosis since the discovery that reelin is 50% down-regulated in postmortem psychotic brain. Brain abnormalities in +/rl are...

Topics

Animals
Behavior, Animal
Brain
Cell Adhesion Molecules, Neuronal
Disease Models, Animal
Down-Regulation
Extracellular Matrix Proteins
Glutamate Decarboxylase
Humans
Isoenzymes
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Tissue Proteins

Neurons

Phenotype

Psychotic Disorders

Reelin Protein

Serine Endopeptidases

gamma-Aminobutyric Acid

Source

Open in PubMed

Identifiers

PMID: 16769115
DOI: 10.1016/j.neubiorev.2006.04.001

Genes

RELN
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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