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Cortical excitatory and inhibitory neuron deficits may underlie the cognitive and social impairments in a mouse model of schizophrenia with exonic <i>Reln</i> deletion

2025-07-25

Abstract excerpt

Reelin is an essential extracellular matrix glycoprotein involved in the formation of cortical layers and has been associated with several neuropsychiatric conditions, such as schizophrenia (SCZ). To explore its role in brain function and its potential involvement in SCZ, we developed a Reln heterozygous deletion ( Reln del/+ ) mouse model that mimics a genetic deletion observed in a Japanese patient with SCZ....

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Literature Corpus work
2bd4333a-cc56-593c-a910-7e09f5804574
DOI
10.1101/2025.07.21.666057
Open publication

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Cortical excitatory and inhibitory neuron deficits may underlie the cognitive and social impairments in a mouse model of schizophrenia with exonic <i>Reln</i> deletionDOI 10.1101/2025.07.21.666057
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