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SLC39-driven zinc influx orchestrates pleiotropic tumor–immune crosstalk to establish an immune-suppressive microenvironment in colorectal cancer

2025-12-22

Abstract excerpt

<title>Abstract</title> <p> Tumor metabolic reprogramming profoundly influences immune regulation, yet the mechanisms linking solute carrier (SLC) transporter activity to immune suppression remain elusive. Through integrative multi-omics, spatial, and single-cell analyses of colorectal cancer (CRC), we uncover a zinc influx–driven signaling axis mediated by the SLC39 family that establishes an immune-suppressive...

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Literature Corpus work
66390258-1320-52f7-be1d-34267774f9a9
DOI
10.21203/rs.3.rs-8267774/v1
Open publication

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