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Article

Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer.

Translational research : the journal of laboratory and clinical medicine - 1 Mar 2026

Choi Sang-Pil, Yang Jun, Park In-Byung, Kang Seok-Jin, Park Si-Won, Lee Chang-Hee, Lee Hyeon Jeong, Bae Joonbeom, Choi Chang-Yong, Shin Jiyoon, Kim Ji-In, Jin Hyun Yong, Lee Young Sik, Chun Taehoon

Abstract excerpt

Colorectal cancer (CRC) remains largely resistant to immune checkpoint inhibitors (ICIs) due to an immunosuppressive tumor microenvironment (TME) shaped by M2-like tumor-associated macrophages (TAMs). Identifying transcriptional regulators of M2-like TAMs in CRC could provide strategies to overcome ICI resistance by reprogramming the TME. In this study, we analyzed single-cell RNA-seq data from CRC patients to...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to MafB Transcription Factor

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Source

Identifiers

PMID: 41692233
DOI: 10.1016/j.trsl.2026.02.006

Genes

MAFB
MAF
STAT3
STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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