Microbial induction of MHC-II expression in colon cancer cells overcomes immunotherapy resistance and limits metastasis

Abstract excerpt

<h4>SUMMARY</h4> Colorectal cancer remains a major cause of cancer mortality, and most microsatellite stable tumors derive little benefit from immune checkpoint blockade. Here, we identify a microbiome-dependent mechanism that converts immune-refractory colorectal cancer into a more immunologically responsive state. Using orthotopic mouse models spanning distinct genetic and immunologic contexts, we show that a H...

Topics

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• Combined Modality Therapy
• Disease Management
• Disease Susceptibility
• Gastrointestinal Microbiome
• Host-Pathogen Interactions
• Immune Checkpoint Inhibitors
• Immunotherapy
• Molecular Targeted Therapy

Identifiers and source

Literature Corpus work

5a965144-d4b9-5440-8c33-a947a2ec7fa4

DOI

10.64898/2026.06.30.735621