Article

Antigen Specificity and Cell Engineering Determine CAR T Cell Efficacy in Group 3 Medulloblastoma

2026-02-19

Abstract excerpt

<title>Abstract</title> <p> Group 3 medulloblastoma (G3MB) is a devastating disease of the central nervous system (CNS) that primarily affects infants and children. Chimeric antigen receptor (CAR) T cell therapy holds the promise to improve outcomes for CNS malignancies, but few studies have focused specifically on G3MB. We used publicly available datasets to demonstrate EphA2 and B7-H3 expression in primary G3M...

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Literature Corpus work: dc9a8643-17d8-5b0e-820f-b67f6529be8c
DOI: 10.21203/rs.3.rs-8863171/v1

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