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IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas

2024-12-11

Abstract excerpt

<title>Abstract</title> <p>Pediatric high-grade gliomas (pHGG) and pediatric diffuse midline gliomas (pDMG) are devastating diseases without durable and curative options. Although targeted immunotherapy has shown promise, the field lacks immunocompetent animal models to study these processes in detail. To achieve this, we developed a fully immunocompetent, genetically engineered mouse model (GEMM) for pDMG and pH...

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Literature Corpus work
cef4b8a9-39aa-5c66-82ad-19e196b0c5f9
DOI
10.21203/rs.3.rs-5398280/v1
Open publication

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IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomasDOI 10.21203/rs.3.rs-5398280/v1
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