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Targeting B7‑H3 through EZH2 inhibition in MYC‑positive Group 3 medulloblastoma

27 Apr 2023

Abstract excerpt

The most aggressive subtype of medulloblastoma (MB), Group 3, is characterized by MYC amplifications. However, targeting MYC has proven unsuccessful, and there remains a lack of therapeutic targets for treating MB. Studies have shown that the B7 homolog 3 (B7‑H3) promotes cell proliferation and tumor cell invasion in a variety of cancers. Similarly, it was recently revealed that B7‑H3 promotes angiogenesis in...

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PMID: 37114557
DOI: 10.3892/or.2023.8556

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