Article

ORF Capture-Seq: a versatile method for targeted identification of full-length isoforms

2019-04-11

Abstract excerpt

Most human protein-coding genes are expressed as multiple isoforms. This in turn greatly expands the functional repertoire of the encoded proteome. While at least one reliable open reading frame (ORF) model has been assigned for every gene, the majority of alternative isoforms remains uncharacterized experimentally. This is primarily due to: i) vast differences of overall levels between different isoforms expresse...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dc5e3e9d-141e-5de2-84a2-dcf0f13085ba
DOI: 10.1101/604157

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ORF Capture-Seq: a versatile method for targeted identification of full-length isoformsDOI 10.1101/604157Read

SCOTCH: isoform-level characterization of gene expression through long-read single-cell RNA sequencingSemantic proximity Read

Ribosome profiling at isoform level reveals an evolutionary conserved impact of differential splicing on the proteomeSemantic proximity Read

Quantification of translation uncovers the functions of the alternative transcriptomeSemantic proximity Read

An integrated landscape of mRNA and protein isoformsSemantic proximity Read

Comprehensive characterization of single cell full-length isoforms in human and mouse with long-read sequencingSemantic proximity Read

LRP2: A proteogenomics pipeline for long-read informed protein isoform analysis and discoverySemantic proximity Read

Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversitySemantic proximity Read

What can Ribo-seq and proteomics tell us about the non-canonical proteome?Semantic proximity Read

An algorithmic framework for isoform-specific functional analysisSemantic proximity Read

Long-read isoform sequencing reveals survival-associated splicing in breast cancerSemantic proximity Read

hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.Semantic proximity Read

Highly accurate isoform identification for the human transcriptomeSemantic proximity Read