Article

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

2024-04-13

Abstract excerpt

<h4>ABSTRACT</h4> Diffuse gliomas are epigenetically dysregulated, immunologically cold, and fatal tumors characterized by mutations in isocitrate dehydrogenase (IDH). Although IDH mutations yield a uniquely immunosuppressive tumor microenvironment, the regulatory mechanisms that drive the immune landscape of IDH mutant (IDHm) gliomas remain unknown. Here, we reveal that transcriptional repression of retinoic aci...

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Literature Corpus work: dc37db5e-fc3f-5a06-8c34-9cf05429255d
DOI: 10.1101/2024.04.09.588752

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