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Article

IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression.

Neuro-oncology - 1 Oct 2016

Zhang Xiaoran, Rao Aparana, Sette Paola, Deibert Christopher, Pomerantz Alexander, Kim Wi Jin, Kohanbash Gary, Chang Yigang, Park Yongseok, Engh Johnathan, Choi Jaehyuk, Chan Timothy, Okada Hideho, Lotze Michael, Grandi Paola, Amankulor Nduka

Abstract excerpt

BACKGROUND: Diffuse gliomas are poorly immunogenic, fatal brain tumors. The basis for insufficient antitumor immunity in diffuse gliomas is unknown. Gain-of-function mutations in isocitrate dehydrogenases (IDH1 and IDH2) promote diffuse glioma formation through epigenetic reprogramming of a number of genes, including immune-related genes. Here, we identify epigenetic dysregulation of natural killer (NK) cell...

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Source

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Identifiers

PMID: 27116977
DOI: 10.1093/neuonc/now061
PMCID: PMC5035522

Genes

ULBP1
ULBP3
IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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