Article

Targeting an RNA Editor to Impede H3K27M+ Pediatric Gliomas

2026-05-12

Abstract excerpt

Diffuse midline glioma (DMG) is a lethal pediatric brain tumor with no curative therapies. Immune checkpoint blockade (ICB) has shown limited efficacy in DMG, largely due to poor T cell infiltration, low immune checkpoint (IC) expression, and a low tumor mutational burden. Here, we identify adenosine deaminase acting on RNA (ADAR), an RNA-editing enzyme that suppresses endogenous dsRNA sensing, as a key mediator o...

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Literature Corpus work: c6bc91f3-7735-50b5-a0fc-ac376124a95e
DOI: 10.64898/2026.05.08.723800

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