Article

G-CSF Secreted by Epigenetically Reprogrammed Mutant IDH1 Glioma Stem Cells Reverses the Myeloid Cells’-Mediated Immunosuppressive Tumor Microenvironment

2020-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Mutation in isocitrate dehydrogenase ( mIDH ) is a gain of function mutation resulting in the production of the oncometabolite, R-2-hydroxyglutarate, that inhibits DNA and histone demethylases. The resultant hypermethylation phenotype reprograms the glioma cells’ transcriptome and elicits profound effects on glioma immunity. We report that in mouse models and human gliomas, mIDH1 in the contex...

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Literature Corpus work: 2b9e95f2-c54f-5677-b588-e23e116fe352
DOI: 10.1101/2020.07.22.215954

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