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Article

ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma.

Genome biology - 11 Nov 2021

Babikir Husam, Wang Lin, Shamardani Karin, Catalan Francisca, Sudhir Sweta, Aghi Manish K, Raleigh David R, Phillips Joanna J, Diaz Aaron A

Abstract excerpt

BACKGROUND: Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prognostic, predictive of response to chemotherapy, and correlate with distinct tumor microenvironments. RESULTS: To reconcile these findings, we profile 22 human IDH-mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34763709
DOI: 10.1186/s13059-021-02535-4
PMCID: PMC8588616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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