Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATRX loss promotes immunosuppressive mechanisms in IDH1 mutant glioma.

Neuro-oncology - 1 Jun 2022

Hu Chengchen, Wang Kimberly, Damon Ceylan, Fu Yi, Ma Tengjiao, Kratz Lisa, Lal Bachchu, Ying Mingyao, Xia Shuli, Cahill Daniel P, Jackson Christopher M, Lim Michael, Laterra John, Li Yunqing

Abstract excerpt

BACKGROUND: ATRX inactivation occurs with IDH1R132H and p53 mutations in over 80% of Grades II/III astrocytomas. It is believed that ATRX loss contributes to oncogenesis by dysregulating epigenetic and telomere mechanisms but effects on anti-glioma immunity have not been explored. This paper examines how ATRX loss contributes to the malignant and immunosuppressive phenotypes of IDH1R132H/p53mut glioma cells and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogenesis

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to Mutation

Share to Tumor Microenvironment

Share to X-linked Nuclear Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 34951647
DOI: 10.1093/neuonc/noab292
PMCID: PMC9159463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATRX loss promotes immunosuppressive mechanisms in IDH1 mutant glioma.PMID 34951647Read ↗

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.Semantic proximity Read ↗

ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma.Semantic proximity Read ↗

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2Semantic proximity Read ↗

ATRX mRNA expression combined with IDH1/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples samples.Semantic proximity Read ↗

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage responseSemantic proximity Read ↗

Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma.Semantic proximity Read ↗

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations.Semantic proximity Read ↗

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.Semantic proximity Read ↗

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axisSemantic proximity Read ↗

IDH1 <sup>R132H</sup> acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage responseSemantic proximity Read ↗

G-CSF Secreted by Epigenetically Reprogrammed Mutant IDH1 Glioma Stem Cells Reverses the Myeloid Cells’-Mediated Immunosuppressive Tumor MicroenvironmentSemantic proximity Read ↗

Evaluation of a DNA demethylating agent in combination with all-trans retinoic acid for IDH1-mutant gliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.