Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas.

doi:10.1093/jnci/djs357

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Article

Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas.

Journal of the National Cancer Institute - 3 Oct 2012

Chou Arthur P, Chowdhury Reshmi, Li Sichen, Chen Weidong, Kim Andrew J, Piccioni David E, Selfridge Julia M, Mody Reema R, Chang Stephen, Lalezari Shadi, Lin Jeffrey, Sanchez Desiree E, Wilson Ryan W, Garrett Matthew C, Harry Bret, Mottahedeh Jack, Nghiemphu Phioanh L, Kornblum Harley I, Mischel Paul S, Prins Robert M, Yong William H, Cloughesy Timothy, Nelson Stanley F, Liau Linda M, Lai Albert

Abstract excerpt

BACKGROUND: Mutations in isocitrate dehydrogenase 1 (IDH1) and associated CpG island hypermethylation represent early events in the development of low-grade gliomas and secondary glioblastomas. To identify candidate tumor suppressor genes whose promoter methylation may contribute to gliomagenesis, we compared methylation profiles of IDH1 mutant (MUT) and IDH1 wild-type (WT) tumors using massively parallel reduced...

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Identifiers

PMID: 22945948
DOI: 10.1093/jnci/djs357
PMCID: PMC3529615

Genes

IDH1
RBP1
IDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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