Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.

doi:10.1038/s41467-024-44932-w

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Article

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.

Nature communications - 25 Jan 2024

Hariharan Seethalakshmi, Whitfield Benjamin T, Pirozzi Christopher J, Waitkus Matthew S, Brown Michael C, Bowie Michelle L, Irvin David M, Roso Kristen, Fuller Rebecca, Hostettler Janell, Dharmaiah Sharvari, Gibson Emiley A, Briley Aaron, Mangoli Avani, Fraley Casey, Shobande Mariah, Stevenson Kevin, Zhang Gao, Malgulwar Prit Benny, Roberts Hannah, Roskoski Martin, Spasojevic Ivan, Keir Stephen T, He Yiping, Castro Maria G, Huse Jason T, Ashley David M

Abstract excerpt

Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH-mutant astrocytomas, have been implicated in dysfunctional immune signaling. However, little is known about the interplay between ATRX loss and IDH mutation on innate immunity. To explore this, we generated ATRX-deficient glioma models...

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Identifiers

PMID: 38272925
DOI: 10.1038/s41467-024-44932-w
PMCID: PMC10810843

Genes

ATRX
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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