Article

Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettes

2021-01-25

Abstract excerpt

<h4>SUMMARY</h4> Our understanding of the human brain is limited by the lack of experimental models to mechanistically probe the properties of brain cells at different developmental stages under normal and pathological conditions. We developed a new method for generating human cortico-striatal organoids from stem cell-derived single neural rosettes (SNRs) and used it to investigate cortico-striatal development an...

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Literature Corpus work: dc350b5e-6add-5c40-ba63-b925b81656f4
DOI: 10.1101/2021.01.25.428022

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