Article
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells.
Nature biotechnology - 1 Dec 2020
Miura Yuki, Li Min-Yin, Birey Fikri, Ikeda Kazuya, Revah Omer, Thete Mayuri Vijay, Park Jin-Young, Puno Alyssa, Lee Samuel H, Porteus Matthew H, Pașca Sergiu P
Abstract excerpt
Cortico-striatal projections are critical components of forebrain circuitry that regulate motivated behaviors. To enable the study of the human cortico-striatal pathway and how its dysfunction leads to neuropsychiatric disease, we developed a method to convert human pluripotent stem cells into region-specific brain organoids that resemble the developing human striatum and include electrically active medium spiny...
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