Human brain organogenesis: Toward a cellular understanding of development and disease.

doi:10.1016/j.cell.2021.10.003

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Article

Human brain organogenesis: Toward a cellular understanding of development and disease.

Cell - 6 Jan 2022

Kelley Kevin W, Pașca Sergiu P

Abstract excerpt

The construction of the human nervous system is a distinctly complex although highly regulated process. Human tissue inaccessibility has impeded a molecular understanding of the developmental specializations from which our unique cognitive capacities arise. A confluence of recent technological advances in genomics and stem cell-based tissue modeling is laying the foundation for a new understanding of human neural...

Topics

Animals
Autism Spectrum Disorder
Brain
Epilepsy
Humans
Mutation
Neurogenesis
Neurons
Organoids
Schizophrenia

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Identifiers

PMID: 34774127
DOI: 10.1016/j.cell.2021.10.003
PMCID: PMC13523617

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