Article
Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia.
Cancer research - 15 Jan 2017
Ding Ling-Wen, Sun Qiao-Yang, Tan Kar-Tong, Chien Wenwen, Mayakonda Anand, Yeoh Allen Eng Juh, Kawamata Norihiko, Nagata Yasunobu, Xiao Jin-Fen, Loh Xin-Yi, Lin De-Chen, Garg Manoj, Jiang Yan-Yi, Xu Liang, Lim Su-Lin, Liu Li-Zhen, Madan Vikas, Sanada Masashi, Fernández Lucia Torres, Hema Preethi S S, Lill Michael, Kantarjian Hagop M, Kornblau Steven M, Miyano Satoru, Liang Der-Cherng, Ogawa Seishi, Shih Lee-Yung, Yang Henry, Koeffler H Phillip
Abstract excerpt
Current standard of care for patients with pediatric acute lymphoblastic leukemia (ALL) is mainly effective, with high remission rates after treatment. However, the genetic perturbations that give rise to this disease remain largely undefined, limiting the ability to address resistant tumors or develop less toxic targeted therapies. Here, we report the use of next-generation sequencing to interrogate the genetic...
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