Article

Complex structural variation is prevalent and highly pathogenic in pediatric solid tumors

2023-09-22

Abstract excerpt

<h4>Background</h4> In pediatric cancer, structural variants (SVs) and copy number alterations can contribute to cancer initiation and progression, and hence aid diagnosis and treatment stratification. The few studies into complex rearrangements have found associations with tumor aggressiveness or poor outcome. Yet, their prevalence and biological relevance across pediatric solid tumors remains unknown. <h4>Resul...

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Literature Corpus work: ce569087-e8ba-585f-94f3-f9b9c75ada3b
DOI: 10.1101/2023.09.19.558241

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