Article

Dictys: dynamic gene regulatory network dissects developmental continuum with single-cell multi-omics

2022-09-17

Abstract excerpt

Gene regulatory networks (GRNs) are key determinants of cell function and identity and are dynamically rewired during development and disease. Despite decades of advancement, challenges remain in GRN inference: dynamic rewiring, causal inference, feedback-loop modeling, and context specificity. To address them, we develop Dictys, a dynamic GRN inference and analysis method which leverages multi-omic single-cell as...

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Literature Corpus work: 6b2e7eae-3db9-50f6-af04-18c55f208cf8
DOI: 10.1101/2022.09.14.508036

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